Animal Models
Charles River is committed to providing you with high quality research animal models. From genetically standard and disease specific models to surgically altered animals, you can trust us to be an integral part of your biomedical research programs.
Animal models form the cornerstone of translational research and drug development. Standardizing them ensures data reliability and reproducibility while preserving the precise biological traits essential for specific studies. Rigorous genetic management is pivotal here, guaranteeing consistent trait expression serving and experimental success.
The Hidden Risks: How Genetic Drift Undermine Your Data?
Without genetic management, Outbred Stocks can suffer from increased inbreeding coefficients due to long-term physical isolation. This leads to genetic divergence in the same strain across different facilities, ultimately undermining the reproducibility of experimental outcomes.
For Inbred Strains, genetic drift can occur within populations, causing shifts in genotype and phenotype profiles. This results in irreproducible experimental results or data that cannot be rationally interpreted.
How do we ensure the genetic stability of our research models?
Breeding uniform animal models that are minimally affected by genetic drift and colony divergence is crucial for research reproducibility worldwide. Our unique International Genetic Standardization (IGS) program is available to manage the health and genetics of your inbred/outbred mice and rat strains to ensure high quality and uniformity, regardless of where they are bred.
International Genetic Standardization (IGS)
Global Consistency: Same genetic background across all Charles River facilities worldwide, refreshed every 3-5 years from core colonies.
Data Reproducibility: Minimizes variability between studies conducted in different locations and times.