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Animal Models
动物模型

Animal models are the cornerstone of translational research and drug development. Standardization of these models not only ensures the reliability and reproducibility of scientific data but also precisely maintains the critical biological characteristics required for specific studies. In this process, rigorous genetic management plays a decisive role, serving as the core element that guarantees stable trait expression and experimental success.
動物模型是轉化研究與藥物開發的關鍵基石。模型的標準化不僅確保了科研數據的可靠性與可重複性,更能精準維持特定研究所需的關鍵生物學特徵。在此過程中,嚴格的遺傳管理發揮著決定性作用,是保障模型穩定表達與實驗成功的核心要素。
The Hidden Risks: How Genetic Drift Undermine Your Data?
潛在風險:遺傳漂變如何破壞您的數據?
Without genetic management, Outbred Stocks can suffer from increased inbreeding coefficients due to long-term physical isolation. This leads to genetic divergence in the same strain across different facilities, ultimately undermining the reproducibility of experimental outcomes.
若缺乏遺傳管理,遠交群體可能因長期的物理隔離而導致近親係數增加。這會造成同一品系在不同設施間出現遺傳分化,最終破壞實驗結果的可重複性。
For Inbred Strains, genetic drift can occur within populations, causing shifts in genotype and phenotype profiles. This results in irreproducible experimental results or data that cannot be rationally interpreted.
對於近交品系,種群內可能發生遺傳漂變,導致基因型和表型特徵發生變化。這會導致實驗結果無法重複,或產生無法被合理解釋的數據。
How do we ensure the genetic stability of our research models?
我們如何確保研究模型的遺傳穩定性?
Breeding uniform animal models that are minimally affected by genetic drift and colony divergence is crucial for research reproducibility worldwide. Our unique International Genetic Standardization (IGS) program is available to manage the health and genetics of your inbred/outbred mice and rat strains to ensure high quality and uniformity, regardless of where they are bred.
培育受遺傳漂變和群落分歧影響最小的均一動物模型,對於全球範圍內的研究可重複性至關重要。我們獨特的國際遺傳學標準化 (IGS) 計劃可用於管理您的近交/遠交小鼠和大鼠品系的健康與遺傳,無論在何處繁殖,都能確保其高質量和均一性。

International Genetic Standardization (IGS)
國際遺傳學標準
Global Consistency: Same genetic background across all Charles River facilities worldwide, refreshed every 3-5 years from core colonies.
全球一致性: Charles River全球所有設施具有相同的遺傳背景,每 3-5 年從核心群更新。
Data Reproducibility: Minimizes variability between studies conducted in different locations and times.
數據可重複性: 最大限度減少不同地點和時間研究間的變異。
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